Cellular therapies in motor neuron diseases
نویسندگان
چکیده
منابع مشابه
Motor Neuron Diseases
Although many use the term ‘motor neuron disease’ to refer to amyotrophic lateral sclerosis (ALS), the most common and serious of these disorders occurring in adults, there are a wide variety of different motor neuron diseases, of varying severity, affecting all ages from infancy onwards (Table 1). This death of motor neurons is a form of neurodegenerative disease and results in paralysis of th...
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BACKGROUND The recently postulated "disease spreading hypothesis" has gained much attention, especially for Parkinson's disease (PD). The various non-motor symptoms (NMS) in neurodegenerative diseases would be much better explained by this hypothesis than by the degeneration of disease-specific cell populations. Motor neuron disease (MND) is primarily known as a group of diseases with a selecti...
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Background Degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. The principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. To briefly review the lines of research and potential candidates for cell based therapies among ...
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Modulation of testosterone levels is a therapeutic approach for spinal and bulbar muscular atrophy (SBMA), a polyglutamine disorder that affects the motor neurons. The article by Palazzolo et al. in this issue of Neuron provides compelling evidence that the expression of insulin growth hormone is a potential therapeutic for SBMA.
متن کاملThe electrophysiology of the motor neuron diseases.
The motor neuron diseases are a set of disorders associated with the selective degeneration of motor neurons. Amyotrophic lateral sclerosis (ALS) is the most common and confers the gravest prognosis. Although ALS occurs with known genetic causes in a small minority, other motor neuron disorders have well-defined genetic mutations. Electrodiagnostic testing is important to distinguish these vari...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2006
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2006.06.004